Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been found to physically interact with many widely expressed “housekeeping” genes. Evidence suggests that their roles at these loci are not to provide binary on/off switches, as is observed at many highly cell‐type specific genes, but rather to serve as governors, directly modulating expression within certain bounds, while not shutting down gene expression. This sort of regulation is challenging to study, as the differential expression levels can be small. We hypothesize (...) that depending on context, corepressors mediate “soft repression,” attenuating expression in a less dramatic but physiologically appropriate manner. Emerging data indicate that such regulation is a pervasive characteristic of most eukaryotic systems, and may reflect the mechanistic differences between repressor action at promoter and enhancer locations. Soft repression may represent an essential component of the cybernetic systems underlying metabolic adaptations, enabling modest but critical adjustments on a continual basis. (shrink)

There have been serious controversies in the latter part of the 20th century about the roles and functions of scientific and medical research. In whose interests are medical and biomedical experiments conducted and what are the ethical implications of experimentation on subjects unable to give competent consent? From the decades following the Second World War and calls for the global banning of medical research to the cautious return to the notion that in controlled circumstances, medical research on human subjects is (...) in the best interest of the given individual and the broader population, this book addresses the key implications of experimentation on humans. This volume covers major ethical themes within biomedical research providing historical, philosophical, legal and policy reflections on the literature and specific issues in the field of research on human subjects. Focusing on special populations (the elderly, children, prisoners and the cognitively impaired) it represents the most up-to-date review of the special ethical and legal conflicts that arise with relation to experimentation on subjects from these groups. In the light of current initiatives for law reform pertaining to research ethics the world over, this volume provides a timely, comprehensive and provocative exploration of the field. The volume has been carefully organized to present important philosophical perspectives on organizing principles that should underlie any practical application. A forward-looking historical review of the regulatory regimes of principal jurisdictions, including of the legal controls already in place, provides the backdrop for future policy initiatives. Additionally, in the light of global restructuring of health care systems, several chapters have been devoted to epidemiological research and related issues. (shrink)

This is an introductory guide to the basic principles of constructing good arguments and criticizing bad ones. It is nontechnical in its approach, and is based on 150 key examples, each discussed and evaluated in clear, illustrative detail. The author explains how errors, fallacies, and other key failures of argument occur. He shows how correct uses of argument are based on sound argument strategies for reasoned persuasion and critical questions for responding. Among the many subjects covered are: techniques of posing, (...) replying to, and criticizing questions, forms of valid argument, relevance, appeals to emotion, personal attack, uses and abuses of expert opinion, problems in deploying statistics, loaded terms, equivocation, and arguments from analogy. (shrink)

Stamos squarely confronts the problem of determining what a biological species is, whether species are real, and the nature of their reality. He critically considers the evolution of the major contemporary views of species and also offers his own solution to the species problem.

Stamos squarely confronts the problem of determining what a biological species is, whether species are real, and the nature of their reality. He critically considers the evolution of the major contemporary views of species and also offers his own solution to the species problem.

This book is designed to appeal both to those interested in Roman poetry and to specialists in ancient philosophy. In it David Sedley explores Lucretius ' complex relationship with Greek culture, in particular with Empedocles, whose poetry was the model for his own, with Epicurus, the source of his philosophical inspiration, and with the Greek language itself. He includes a detailed reconstruction of Epicurus' great treatise On Nature, and seeks to show how Lucretius worked with this as his sole (...) philosophical source, but gradually emancipated himself from its structure, transforming its raw contents into something radically new. By pursuing these themes, the book uncovers many unrecognised aspects of Lucretius ' methods and achievements as a poetic craftsman. (shrink)

Examines Darwin’s concept of species in a philosophical context.

Aristotle claims in the Metaphysics that in order to be resourceful in first philosophic inquiry it is useful to go through perplexity well. In this essay, the author argues that that perplexity plays a parallel role in Aristotle’s account of practical, deliberative inquiry in the Nicomachean Ethics. He does so by offering an interpretation of the relation between Aristotle’s account of akratic ignorance in Nicomachean Ethics 7 and his emphasis on the necessity of going through perplexity when inquiring into akrasia. (...) Along the way, the author tries to shed some additional light on Aristotle’s conception of endoxa, his account of the so-called practical syllogism, and the distinction between ethical virtue simply and “authoritative” virtue. But the intention throughout the essay is to examine the role that perplexity about the phenomena of ethical life plays in Aristotle’s account of the kind of thoughtfulness required for excellence of character. (shrink)

Sophocles' Antigone contains the first recorded instance of the word αὑτ ό νομος, the source for our word “autonomous”. I argue that reflection upon the human aspiration toward autonomy is central to that work. I begin by focusing on the difficulty readers of the play have determining whether Antigone's actions in the play should be considered autonomous and then suggest that recognizing this difficulty is crucial to a proper understanding of the play. The very aspects of Antigone's character that seem (...) to militate against understanding her actions within the play as autonomous—her rejection of life, her intimacy with death and the way she seems defined by her incestuous heritage— serve to illustrate the inherently problematic character of a moral ideal that we can provisionally call Antigone's autonomy. I show how the movement of the play can be understood in terms of Antigone's progress from what Kant would characterize as a heteronomous representation of her irremissible duty to bury her dead brother, to a self-conception defined by a recognition and embrace of her autonomy understood as, in Kant's words, “a respect for something entirely different from life”. Antigone's autonomy is exemplified by her choice to be dead, the choice to bear the burden of responsibility to her own. This choice, I argue, must be understood as the choice of herself as defined by her obligation to her own. Sophocles' Antigone suggests that the moral ideal Antigone represents is unliveable, but that this ideal is nonetheless essential to human moral aspiration. (shrink)

This provocative text considers whether evolutionary explanations can be used to clarify some of life’s biggest questions. Examines topics of race, sex, gender, the nature of language, religion, ethics, knowledge, consciousness and ultimately, the meaning of life Each chapter presents a main topic, together with discussion of related ideas and arguments from various perspectives Addresses questions such as: Did evolution make men and women fundamentally different? Is the concept of race merely a social construction? Is morality, including universal human rights, (...) a mass delusion? Can religion and evolution really be harmonized? Does evolution render life meaningless? Written in a clear and informative style, with helpful references for further reading and research. (shrink)

In Freedom's Right Axel Honneth seeks to provide a theory of justice by appropriating Hegel's account of ethical substance in the Philosophy of Right, but he wants to do so without endorsing Hegel's more robust idealist commitments. I argue that this project can only succeed if Honneth can offer an alternative, comparatively robust demonstration of the rationality and normative coherence of existing social institutions. I contend that the grounds Honneth provides for this claim are insufficient for his purposes. In particular, (...) I argue that Honneth's claim that “justice and individual self-determination are mutually referential,” even were it to be accepted, would be insufficient to underwrite his more robust identification between the normative foundations of justice, autonomy and reciprocal self-realization. In the final section of the paper, I turn to Honneth's analysis of the “social institution” of friendship, which he, following Hegel, holds up as a paradigmatic instantiation of social freedom understood as, in Hegel's words, “being with oneself in another” . I argue that an analysis of the normative import of friendship wholly in terms of mutual recognition misses an important aspect of the kind of self-realization that friendship makes possible. (shrink)

This provocative text considers whether evolutionary explanations can be used to clarify some of life’s biggest questions. Examines topics of race, sex, gender, the nature of language, religion, ethics, knowledge, consciousness and ultimately, the meaning of life Each chapter presents a main topic, together with discussion of related ideas and arguments from various perspectives Addresses questions such as: Did evolution make men and women fundamentally different? Is the concept of race merely a social construction? Is morality, including universal human rights, (...) a mass delusion? Can religion and evolution really be harmonized? Does evolution render life meaningless? Written in a clear and informative style, with helpful references for further reading and research. (shrink)

In addition to the distinction between species as a category and speciesas a taxon, the word species is ambiguous in a very different butequally important way, namely the temporal distinction between horizontal andvertical species. Although often found in the relevant literature, thisdistinction has thus far remained vague and undefined. In this paper the use ofthe distinction is explored, an attempt is made to clarify and define it, andthen the relation between the two dimensions and the implications of thatrelation are examined. (...) Using Darwin's analogy of language evolution forspeciesevolution, and by appealing to a major change in the conception of languagebetween 19th- and 20th-century linguistics, it is argued that the horizontaldimension has priority (pragmatic, epistemological, logical, and ontological)over the vertical dimension. This has immense ramifications for the modernspecies problem. Fundamentally, it favors horizontal species concepts oververtical ones. In so doing it places species realism on a much more securefoundation and largely undercuts species pluralism. In addition it raises aserious problem for the increasingly popular family of phylogenetic speciesconcepts, which generally suffer from a dimensionality confusion. However,thereis a recent trend within this family that attempts to restore the priority ofthe horizontal dimension. It is concluded that this trend should be affirmedandthat the species-as-individuals view should be abandoned. (shrink)

In this book, David McNeill illuminates Plato’s distinctive approach to philosophy by examining how his literary portrayal of Socrates manifests an essential interdependence between philosophic and ethical inquiry. In particular, McNeill demonstrates how Socrates’s confrontation with profound ethical questions about his public philosophic activity is the key to understanding the distinctively mimetic, dialogic, and reflexive character of Socratic philosophy. Taking a cue from Nietzsche’s account of “the problem of Socrates,” McNeill shows how the questions Nietzsche raises are questions that, (...) in Plato's depiction, Socrates was aware of and responded to. McNeill also shows how the Republic provides a view of Socratic moral psychology that resembles Nietzsche’s account of human psychology: it deals with the internalized ethical narratives and justificatory schemes through which human beings orient themselves to their world. McNeill argues that this moral psychology not only determines Socrates’s explicit account of different character types and political regimes but also crucially informs his dialectical engagements with his various interlocutors in the dialogues. In addition to contributing a unique perspective to current debates about Socrates’s philosophic methods and the significance of the literary character of Plato’s dialogues, the book offers a far-reaching interpretation of Plato’s presentation of the theoretical and practical activities of the fifth-century Sophists. And in showing how Plato responds to “modern” theoretical challenges, McNeill provides new evidence to question standard views of the differences between ancient and modern conceptions of the self, society, and nature. (shrink)

This is the compelling story of one of the most fascinating thinkers of the twentieth century- a richly toned portrait of a modern-day Thoreau.

This article addresses all of the issues involved in the debate about whether or not bioethicists should be paid by private biomedical companies to perform consultations. These issues include the following: differentiation of this role from bioethicists' other roles, an analysis of to whom bioethicists owe a duty, consideration of what bioethicists are “selling,” whether bioethicists should be allowed to get paid, when payment becomes problematic, and whether consulting fee arrangements should be regulated. The author often compares bioethicists' relationship to (...) the companies to bioethicists' other relationships, as well as to professional relationships in other fields, such as law and accounting. (shrink)

Bioethics, once a four-letter word in the private sector, is now an integral part of the decisionmaking process of biotechnology and pharmaceutical companies. And bioethicists, once confined to the classroom and limited to abstract, philosophical discussions about what is right and wrong in medicine and medical research, now play an important role in the practical implementation of ethical boundaries. Bioethicists increasingly are hired by biomedical companies as consultants to highlight and help resolve complex ethical issues that arise in the companies’ (...) normal business practices. Whether motivated by profit, reputation, or a genuine desire to act morally, these companies are willing to pay bioethicists substantial consultation fees for their “expert” opinions. This fairly recent phenomenon has caused some to be concerned about the potential for bioethicists to encounter conflicts of interests. Specifically, many critics of this new relationship between bioethicists and the private sector “are concerned about the appropriateness of ethicists who should have broader interests, such as concerns about social justice, serving clients whose primary interest is profit-maximizing.”. (shrink)

As disciplines, psychology and theology share an overlapping interest in the nature and functioning of human beings. This book provides an introduction to many of the worldview issues and philosophical foundations that frame the relationship of psychology and theology, includes scholarly reflection on the integration literature, and surveys five paradigms of possible relationships between psychology and Christianity. Questions at the end of each chapter are included to help readers evaluate both the material and their own burgeoning approach to integration. This (...) book is ideal as a textbook for students of psychology and other behavioral and social sciences (social work, sociology, theology, counseling, pastoral counseling) at both the graduate and undergraduate level. It is also written for the broader readership of psychologists, counselors, pastors, and others who are interested in integration" -- Publisher description. (shrink)

In "The Indeterministic Character of Evolutionary Theory: No 'Hidden Variables Proof' But No Room for Determinism Either," Brandon and Carson (1996) argue that evolutionary theory is statistical because the processes it describes are fundamentally statistical. In "Is Indeterminism the Source of the Statistical Character of Evolutionary Theory?" Graves, Horan, and Rosenberg (1999) argue in reply that the processes of evolutionary biology are fundamentally deterministic and that the statistical character of evolutionary theory is explained by epistemological rather than ontological considerations. In (...) this paper I focus on the topic of mutation. By focusing on some of the theory and research on this topic from early to late, I show how quantum indeterminism hooks up to point mutations (via tautomeric shifts, proton tunneling, and aqueous thermal motion). I conclude with a few thoughts on some of the wider implications of this topic. (shrink)

Mary Winsor (2003) argues against the received view that pre-Darwinian taxonomy was characterized mainly by essentialism. She argues, instead, that the methods of pre-Darwinian taxonomists, in spite of whatever their beliefs, were that of clusterists, so that the received view, propagated mainly by certain modern biologists and philosophers of biology, should at last be put to rest as a myth. I argue that shes right when it comes to higher taxa, but wrong when it comes the most important category of (...) all, the species category. (shrink)

Ever since Charles Darwin's On the Origin of Species was published, the received view has been that Darwin literally thought of species as not extra-mentally real. In 1969 Michael Ghiselin upset the received view by interpreting Darwin to mean that species taxa are indeed real but not the species category. In 1985 John Beatty took Ghiselin's thesis a step further by providing a strategy theory to explain why Darwin would say one thing (his repeated nominalistic definition of species) and do (...) another (hold that species taxa are real). In the present paper I attempt to take this line of interpretation to a new level. Guided by the principle of charity, I provide and analyze a considerable amount of evidence from Darwin's mature writings (both private and published) to show that (contra Ghiselin and Beatty) Darwin did not simply accept the species delimitations of his fellow naturalists but actually employed, repeatedly and consistently, a species concept in a thoroughly modern sense, albeit with an implicit definition, a concept uniquely his own and fully in accord with his theory of evolution by natural selection. This implicit concept and definition is carefully reconstructed in the present paper. A new strategy theory is then provided to account for why Darwin would define species (both taxa and category) nominalistically on the one hand but delimit species realistically on the other. (shrink)

Nineteenth-century European thought, especially in Germany, was increasingly dominated by a new historicist impulse to situate every event, person, or text in its particular context. At odds with the transcendent claims of philosophy and--more significantly--theology, historicism came to be attacked by its critics for reducing human experience to a series of disconnected moments, each of which was the product of decidedly mundane, rather than sacred, origins. By the late nineteenth century and into the Weimar period, historicism was seen by many (...) as a grinding force that corroded social values and was emblematic of modern society's gravest ills. Resisting History examines the backlash against historicism, focusing on four major Jewish thinkers. David Myers situates these thinkers in proximity to leading Protestant thinkers of the time, but argues that German Jews and Christians shared a complex cultural and discursive world best understood in terms of exchange and adaptation rather than influence.After examining the growing dominance of the new historicist thinking in the nineteenth century, the book analyzes the critical responses of Hermann Cohen, Franz Rosenzweig, Leo Strauss, and Isaac Breuer. For this fascinating and diverse quartet of thinkers, historicism posed a stark challenge to the ongoing vitality of Judaism in the modern world. And yet, as they set out to dilute or eliminate its destructive tendencies, these thinkers often made recourse to the very tools and methods of historicism. In doing so, they demonstrated the utter inescapability of historicism in modern culture, whether approached from a Christian or Jewish perspective. (shrink)

An awareness of the significance of location in the production and dissemination of scientific knowledge has brought a new dimension to recent work on the sociology of science. But the importance of speech in scientific enterprises has been less well developed. This article explores the idea of `spaces of speech' by underscoring the connections between location and locution. It develops a case study of how Darwinian evolution was talked about in different sites using examples from Ireland and the American South (...) during the latter part of the 19th century. These reveal how sites enable and constrain what may be said, and heard, about particular scientific claims, and how they are crucial to understanding the circulation of scientific claims in public arenas. (shrink)

When in 2001 Earth Liberation Front activists drove metal spikes into hundreds of trees in Gifford Pinchot National Forest, they were protesting the sale of a section of the old-growth forest to a timber company. But ELF's communiqu on the action went beyond the radical group's customary brief. Drawing connections between the harms facing the myriad animals who make their home in the trees and the struggles for social justice among ordinary human beings resisting exclusion and marginalization, the dispatch declared, (...) "all oppression is linked, just as we are all linked," and decried the "patriarchal nightmare" in the form of "techno-industrial global capitalism." In Total Liberation, David Naguib Pellow takes up this claim and makes sense of the often tense and violent relationships among humans, ecosystems, and nonhuman animal species, expanding our understanding of inequality and activists' uncompromising efforts to oppose it. Grounded in interviews with more than one hundred activists, on-the-spot fieldwork, and analyses of thousands of pages of documents, websites, journals, and zines, Total Liberation reveals the ways in which radical environmental and animal rights movements challenge inequity through a vision they call "total liberation." In its encounters with such infamous activists as scott crow, Tre Arrow, Lauren Regan, Rod Coronado, and Gina Lynn, the book offers a close-up, insider's view of one of the most important--and feared--social movements of our day. At the same time, it shows how and why the U.S. justice system plays to that fear, applying to these movements measures generally reserved for "jihadists"--with disturbing implications for civil liberties and constitutional freedom. How do the adherents of "total liberation" fight oppression and seek justice for humans, nonhumans, and ecosystems alike? And how is this pursuit shaped by the politics of anarchism and anticapitalism? In his answers, Pellow provides crucial in-depth insight into the origins and social significance of the earth and animal liberation movements and their increasingly common and compelling critique of inequality as a threat to life and a dream of a future characterized by social and ecological justice for all. (shrink)

In this paper, I argue that genuine ethical deliberation, and hence ethical agency, is incompatible in principle with the possession of determinate practical prescriptions concerning how best to act in a concrete ethical situation. I make this argument principally by way of an analogy between gameplay and ethical deliberation. I argue that trivially solved games of perfect information (the example I use is tic‐tac‐toe) are, or become, in some sense unplayable for the individual for whom the game is trivially solved. (...) The reason for this, I suggest, is that there ceases to be space within the game for the distinction between that individual being a better and being a worse player of the game. I then use this example as an occasion to reflect on the kind of epistemic indeterminacy that appears to be a condition of genuine ethical deliberation. (shrink)

First, a brief history is provided of Popper's views on the status of evolutionary biology as a science. The views of some prominent biologists are then canvassed on the matter of falsifiability and its relation to evolutionary biology. Following that, I argue that Popper's programme of falsifiability does indeed exclude evolutionary biology from within the circumference of genuine science, that Popper's programme is fundamentally incoherent, and that the correction of this incoherence results in a greatly expanded and much more realistic (...) concept of what is empirical, resulting in the inclusion of evolutionary biology. Finally, this expanded concept of empirical is applied to two particular problems in evolutionary biology — viz., the species problem and the debate over the theory of punctuated equilibria — and it is argued that both of them are still mainly metaphysical. (shrink)

Gayon's recent claim that Buffon developed a concept of species as physical individuals is critically examined and rejected. Also critically examined and rejected is Gayon's more central thesis that as a consequence of his analysis of Buffon's species concept, and also of Darwin's species concept, it is clear that modern evolutionary theory does not require species to be physical individuals. While I agree with Gayon's conclusion that modern evolutionary theory does not require species to be physical individuals, I disagree with (...) his reasons and instead provide logical rather than historical reasons for the same conclusion. (shrink)

IN BOOK 9 OF THE REPUBLIC, Socrates tells Adeimantus that the “tyrantmakers” manage to defeat the relatives of the nascent tyrant in the battle over the young man’s soul by contriving “to make in him some eros, a sort of great winged drone, to be the leader of the idle desires.” This “leader of the soul,” Socrates claims.